DESIGN AND MATHEMATICAL ANALYSIS OF ACTIVATING TRANSCRIPTIONAL AMPLIFIERS THAT ENABLE MODULAR TEMPORAL CONTROL IN SYNTHETIC JUXTACRINE CIRCUITS

Design and mathematical analysis of activating transcriptional amplifiers that enable modular temporal control in synthetic juxtacrine circuits

The ability to control mammalian cells such that they self-organize or enact therapeutic effects as desired has incredible implications.Not only would it further our understanding of native processes such as development and the immune response, but it would also have powerful applications in medical fields such as regenerative medicine and immunoth

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Robustifying and simplifying high-dimensional regression with applications to yearly stock return and telematics data

Abstract The availability of many variables with predictive power makes their selection in a regression context difficult.This study considers robust and Gummies understandable low-dimensional estimators as building blocks to improve overall predictive power by optimally combining these building blocks.Our new algorithm is based on generalized cros

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